Escyna ma potwierdzoną skuteczność w leczeniu przewlekłej niewydolności żylnej.Stosowanie wyciągu z kasztanowca standaryzowanego na zawartość escyny (16-20%) znosiło w badaniach klinicznych takie objawy jak nabrzmienie żylaków, bóle, zmęczenie, napięcie i obrzęk nóg, a także świąd.^{[1][2][3][4][5][6][7][8][9][10][11][12]}

Piśmiennictwo

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2. Greeske K, Pohlmann BK. Horse chestnut seed extract-an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency. Fortschr Med 1996;114:196-200. abstrakt.⬏
3. Diehm C, Trampisch HJ, Lange S, Schmidt C. Comparison of leg compression stocking and oral horse-chestnut seed extract in patients with chronic venous insufficiency. Lancet 1996;347:292-4. abstrakt.⬏
4. Diehm C, Vollbrecht D, Amendt K, Comberg HU. Medical edema protection-clinical benefit in patients with chronic deep vein incompetence. Vasa 1992;21:188-92. abstrakt.⬏
5. Bisler H, Pfeifer R, Kluken N, Pauschinger P. [Effects of horse-chestnut seed on transcapillary filtration in chronic venous insufficiency]. Dtsch Med Wochenschr 1986;111:1321-9. abstrakt.⬏
6. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd.⬏
7. Ottillinger, B. and Greeske, K. Rational therapy of chronic venous insufficiency–chances and limits of the therapeutic use of horse-chestnut seeds extract. BMC.Cardiovasc.Disord. 2001;1(1):5. abstrakt.⬏
8. Siebert, U., Brach, M., Sroczynski, G., and Berla, K. Efficacy, routine effectiveness, and safety of horsechestnut seed extract in the treatment of chronic venous insufficiency. A meta-analysis of randomized controlled trials and large observational studies. Int Angiol. 2002;21(4):305-315. abstrakt.⬏
9. Pittler, M. H. and Ernst, E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane.Database.Syst.Rev. 2012;11:CD003230. abstrakt.⬏
10. Friederich, H. C., Vogelsberg, H., and Neiss, A. [Evaluation of internally effective venous drugs]. Z.Hautkr. 6-1-1978;53(11):369-374. abstrakt.⬏
11. Rehn, D., Unkauf, M., Klein, P., Jost, V., and Lucker, P. W. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency. Arzneimittelforschung 1996;46(5):483-487. abstrakt.⬏
12. Rudofsky G and et al. Odemprotektive wirkung und klinische wirksamkeit von ro kastaniensamenextrakt im doppeltblindversuch. Phleb Prokto 1986;15(2):47-54.⬏